Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex

Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex

RNA activation (RNAa) is an uncharacterized mechanism of transcriptional activation mediated by small RNAs, such as microRNAs (miRNAs). A critical issue in RNAa research is that it is difficult to distinguish between changes in gene expression caused indirectly by post-transcriptional regulation and...

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Bibliographic Details
Main Authors: Harada, Y. (Author), Ikeda, N. (Author), Kanekura, K. (Author), Kudo, Y. (Author), Kuroda, M. (Author), Mirza, A. (Author), Nagase, K. (Author), Ochiya, T. (Author), Ohno, S.-I (Author), Oikawa, K. (Author), Ono, K. (Author), Shimada, Y. (Author), Takanashi, M. (Author), Tateishi, M. (Author), Tsurui, T. (Author), Wang, X. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
CDK9
CP: Molecular biology
DDX21
divergent transcription
microRNA
miR-34
promoter-associated noncoding RNA
RNA activation
small activating RNA
ZMYND10
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