Dynamic immunodominance hierarchy of neutralizing antibody responses to evolving GII.4 noroviruses
A paradigm of RNA viruses is their ability to mutate and escape from herd immunity. Because antibody responses are a major effector for viral immunity, antigenic sites are usually under strong diversifying pressure. Here, we use norovirus as a model to study mechanisms of antigenic diversification o...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |