Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial

Background: Pulmonary vascular microthrombi are a proposed mechanism of COVID-19 respiratory failure. We hypothesized that early administration of tissue plasminogen activator (tPA) followed by therapeutic heparin would improve pulmonary function in these patients. Research Question: Does tPA improv...

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Main Authors:	Ammons, L.A (Author), Anez-Bustillos, L. (Author), Baedorf-Kassis, E.N (Author), Banner-Goodspeed, V. (Author), Barrett, C.D (Author), Biffl, W.L (Author), Borrego, R. (Author), Bull, T.M (Author), Capers, K. (Author), Chandler, J. (Author), Dandan, T. (Author), Dhupa, A. (Author), Douglas, I.S (Author), Ghasabyan, A. (Author), Grossman Verner, H.M (Author), Hajizadeh, N. (Author), Jhunjhunwala, R. (Author), Khan, B. (Author), Lottenberg, L. (Author), McCaul, D.S (Author), McDaniel, C. (Author), McIntyre, R.C., Jr (Author), Moore, E.E (Author), Moore, H.B (Author), Moore, P.K (Author), Patel, P.R (Author), Pearcy, C. (Author), Ramdeo, R. (Author), Rueda, M. (Author), Sarkar, P.K (Author), Sauaia, A. (Author), Schmidt, E.P (Author), Shaefi, S. (Author), Sreevidya, C. (Author), Talmor, D.S (Author), Truitt, M.S (Author), Wang, J. (Author), Wright, F.L (Author), Yaffe, M.B (Author)
Format:	Article
Language:	English
Published:	Elsevier Inc. 2022
Subjects:	abdominal bleeding activated partial thromboplastin time adolescent Adolescent adult Adult adult respiratory distress syndrome aged Aged alteplase anemia ARDS arterial oxygen saturation artery thrombosis Article artificial ventilation bacteremia benzodiazepine biliary tract disease bleeding blood bolus injection brain disease brain hemorrhage brain radiography bronchus obstruction candidiasis cerebrovascular accident clinical article clinical outcome clinical trial complication constipation controlled study coronavirus disease 2019 COVID-19 Cross-Sectional Studies cross-sectional study decubitus deep vein thrombosis dehydration delirium dexamethasone diarrhea disease exacerbation disease severity drug eruption drug fever drug safety drug withdrawal dysphagia dysphonia eosinophilia epidemiology epistaxis face edema female Female fibrinolysis fibrinolytic agent Fibrinolytic Agents fibrinolytic therapy follow up Follow-Up Studies fraction of inspired oxygen fracture health care quality heart arrhythmia hematuria hemoptysis heparin human Humans hyperglycemia hyperkalemia hypernatremia hypertension hypertransaminasemia hypervolemia hypoglycemia hypokalemia hyponatremia hypotension hypovolemia ileus in-hospital mortality kidney failure kidney tubule acidosis leukocytosis liver failure lung embolism male Male metabolic alkalosis middle aged Middle Aged mortality multicenter study multiple organ failure myopathy neurologic examination open study opiate oral bleeding outcome assessment pandemic Pandemics partial thromboplastin time Partial Thromboplastin Time peritonitis phase 1 clinical trial phase 2 clinical trial phimosis pleura effusion pneumatocele pneumonia pneumothorax pulmonary failure pulmonary hypertension pulmonary thrombosis randomized controlled trial rectum hemorrhage remdesivir respiratory alkalosis respiratory failure Respiratory Insufficiency Retrospective Studies retrospective study SARS-CoV-2 sepsis septic shock sinusitis thrombocytosis thrombosis Thrombosis tissue plasminogen activator Tissue Plasminogen Activator tissue plasminogen activator (tPA) tongue edema treatment outcome Treatment Outcome urinary tract infection urine retention vagina bleeding vomiting young adult Young Adult
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Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial

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