Six-year absolute invasive disease-free survival benefit of adding adjuvant pertuzumab to trastuzumab and chemotherapy for patients with early HER2-positive breast cancer: A Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of the APHINITY (BIG 4-11) trial

Six-year absolute invasive disease-free survival benefit of adding adjuvant pertuzumab to trastuzumab and chemotherapy for patients with early HER2-positive breast cancer: A Subpopulation Treatment Effect Pattern Plot (STEPP) analysis of the APHINITY (BIG 4-11) trial

Aim: The APHINITY trial showed that adding adjuvant pertuzumab (P) to trastuzumab and chemotherapy, compared with adding placebo (Pla), significantly improved invasive disease-free survival (IDFS) for patients with HER2+ early breast cancer both overall and for the node-positive (N+) cohort. We expl...

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Bibliographic Details
Main Authors: APHINITY Steering Committee and Investigators (Author), Bines, J. (Author), Caballero, C. (Author), Cameron, D. (Author), Cardoso, F. (Author), Clark, E. (Author), Cole, B.F (Author), de Azambuja, E. (Author), Frank, E. (Author), Fumagalli, D. (Author), Gelber, R.D (Author), Heeson, S. (Author), Kiermaier, A. (Author), Krop, I. (Author), Loi, S. (Author), Loibl, S. (Author), Piccart-Gebhart, M. (Author), Procter, M. (Author), Restuccia, E. (Author), Salgado, R. (Author), Tjan-Heijnen, V. (Author), Wang, X.V (Author)
Format: Article
Language:English
Published: Elsevier Ltd 2022
Subjects:
adjuvant chemotherapy
adjuvant therapy
Adjuvant therapy
Article
cancer adjuvant therapy
cancer chemotherapy
cancer patient
cancer survival
cohort analysis
controlled study
disease free survival
female
gene amplification
genetic susceptibility
HER2-positive early breast cancer
human
human epidermal growth factor receptor 2 positive breast cancer
immunohistochemistry
lymphocyte percentage
pertuzumab
Pertuzumab
placebo
risk assessment
STEPP (Subpopulation Treatment Effect Pattern Plot)
TILs (tumour infiltrating lymphocytes)
trastuzumab
Trastuzumab
tumor associated leukocyte
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