Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis

Objective: Hypertension is a major risk factor for intimal hyperplasia (IH) and re-stenosis following vascular and endovascular interventions. Preclinical studies suggest that hydrogen sulphide (H2S), an endogenous gasotransmitter, limits re-stenosis. While there is no clinically available pure H2S...

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Bibliographic Details
Main Authors:	Allagnat, F. (Author), Corpataux, J.-M (Author), Déglise, S. (Author), Deslarzes-Dubuis, C. (Author), Lambelet, M. (Author), Longchamp, A. (Author), Macabrey, D. (Author), Ozaki, C.K (Author)
Format:	Article
Language:	English
Published:	W.B. Saunders Ltd 2022
Subjects:	ACE inhibitor Angiotensin-Converting Enzyme Inhibitors animal Animals blood pressure Blood Pressure captopril Captopril Carotid Arteries carotid artery carotid artery obstruction Carotid Stenosis cell culture Cells, Cultured complication dipeptidyl carboxypeptidase inhibitor disease model Disease Models, Animal drug effect human Humans hydrogen sulfide Hydrogen Sulfide Hydrogen sulphide hyperplasia Hyperplasia hypertension Hypertension intima Intimal hyperplasia male Male metabolism Mice mouse Myocytes, Smooth Muscle organ culture technique Organ Culture Techniques pathology primary cell culture Primary Cell Culture Proliferation Restenosis smooth muscle cell Smooth muscle cells Tunica Intima vein Veins zofenopril Zofenopril
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Hydrogen Sulphide Release via the Angiotensin Converting Enzyme Inhibitor Zofenopril Prevents Intimal Hyperplasia in Human Vein Segments and in a Mouse Model of Carotid Artery Stenosis

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