Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis

Inflammation-dependent oxidative stress metabolites as a hallmark of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, with poor prognosis and no cure. Substantial evidence implicates inflammation and associated oxidative stress as a potential mechanism for ALS, especially in patients carrying the SOD1 mutation and, therefore, lacking an...

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Bibliographic Details
Main Authors: Byzova, T.V (Author), Chen, J. (Author), Dudiki, T. (Author), Gao, D. (Author), Komuro, H. (Author), McCoy, M. (Author), Milo, A. (Author), Podrez, E.A (Author), Trapp, B. (Author), West, X.Z (Author), Xiong, L. (Author), Yakubenko, V. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis
animal
Animals
Biomarker
Carboxyethylpyrrole
copper zinc superoxide dismutase
degenerative disease
disease model
Disease Models, Animal
genetics
human
Humans
inflammation
Inflammation
Lipid peroxidation
metabolism
Mice
Mice, Transgenic
mouse
mutation
Mutation
Neurodegenerative Diseases
oxidative stress
Oxidative stress
Oxidative Stress
superoxide dismutase
Superoxide Dismutase
Superoxide Dismutase-1
transgenic mouse
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