Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells

Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells

Children with autism spectrum disorders often display dysregulated immune responses and related gastrointestinal symptoms. However, the underlying mechanisms leading to the development of both phenotypes have not been elucidated. Here, we show that mouse offspring exhibiting autism-like phenotypes d...

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Bibliographic Details
Main Authors: Biggs, D.G (Author), Choi, G.B (Author), Huh, J.R (Author), Kim, E. (Author), Kwon, H.-K (Author), Paik, D. (Author), Park, Y. (Author), Ramirez, R.N (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
animal
Animals
autism
autism spectrum disorder
Autism Spectrum Disorder
CD4+ T lymphocyte
CD4-Positive T-Lymphocytes
child
Child
chromatin
Chromatin
Citrobacter
colitis
disease model
Disease Models, Animal
fecal microbiota transplantation
Fecal Microbiota Transplantation
female
Female
Gastrointestinal Microbiome
gut microbiota
human
Humans
immunization
Immunization
immunology
inflammation
Inflammation
inflammatory bowel diseases
interleukin 17
Interleukin-17
interleukin-17A
intestine
intestine flora
Intestines
maternal immune activation
mental disease
metabolism
Mice
microbiology
mouse
neurodevelopmental disorders
Neurodevelopmental Disorders
pregnancy
Pregnancy
prenatal exposure
Prenatal Exposure Delayed Effects
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