Divergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria

Divergent Ca2+/calmodulin feedback regulation of CaV1 and CaV2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria

CaV1 and CaV2 voltage-gated calcium channels evolved from an ancestral CaV1/2 channel via gene duplication somewhere near the stem animal lineage. The divergence of these channel types led to distinguishing functional properties that are conserved among vertebrates and bilaterian invertebrates and c...

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Bibliographic Details
Main Authors: Elkhatib, W. (Author), Gauberg, J. (Author), Senatore, A. (Author), Singh, A. (Author), Smith, C.L (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Animals
Bilateria
Ca 2+
Calcium
Calcium alloys
Calcium channels
Calcium influx
Calmodulin
Cellulars
Divergents
Feedback regulation
Functional features
Functional properties
Gene duplications
Genes
Molecular biology
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