Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity

Inhibitor of glutamine metabolism V9302 promotes ROS-induced autophagic degradation of B7H3 to enhance antitumor immunity

Despite the enormous successes of anti-PD-1/PD-L1 immunotherapy in multiple other cancer types, the overall response rates of breast cancer remain suboptimal. Therefore, exploring additional immune checkpoint molecules for potential cancer treatment is crucial. B7H3, a T-cell coinhibitory molecule,...

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Bibliographic Details
Main Authors: Fu, X. (Author), Huang, X. (Author), Lai, S. (Author), Li, H. (Author), Li, Q. (Author), Li, Z. (Author), Liu, Y. (Author), Qu, F. (Author), Wang, C. (Author), Yao, W. (Author), Yu, J. (Author), Zhang, D. (Author), Zhong, X. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Antitumor immunity
Autophagic degradation
Autophagy
Benign lesion
Breast Cancer
Breast tissues
Breast tumour
Cell culture
Cell death
Diseases
Metabolism
Molecules
Monoclonal antibodies
Patient treatment
Reactive oxygen species
Response rate
T-cells
Therapeutic targets
Tumors
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