c-Abl kinase-mediated phosphorylation of γ-tubulin promotes γ-tubulin ring complexes assembly and microtubule nucleation

c-Abl kinase-mediated phosphorylation of γ-tubulin promotes γ-tubulin ring complexes assembly and microtubule nucleation

Cytoskeletal microtubules (MTs) are nucleated from γ-tubulin ring complexes (γTuRCs) located at MT organizing centers (MTOCs), such as the centrosome. However, the exact regulatory mechanism of γTuRC assembly is not fully understood. Here, we showed that the nonreceptor tyrosine kinase c-Abl was ass...

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Bibliographic Details
Main Authors: Bai, Y. (Author), Cao, C. (Author), Dong, Q. (Author), Gu, J. (Author), Jin, Y. (Author), Liu, H. (Author), Liu, X. (Author), Niu, X. (Author), Song, C. (Author), Tao, Q. (Author), Wang, D. (Author), Wang, G.-F (Author), Yue, J. (Author), Zheng, T. (Author), Zhou, R. (Author), Zhu, L. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Amino acids
Chromosomes
Complex assembly
Cytoskeletal
Enzymes
In-vivo
Microtubule nucleation
Microtubule organizing centers
Microtubules
Morphology
Nucleation
Phosphorylation
Regulatory mechanism
Surface plasmon resonance
Tubulin rings
Tyrosine kinase
γ-tubulin
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