Exploring the glycosylation of mucins by use of O-glycodomain reporters recombinantly expressed in glycoengineered HEK293 cells

Exploring the glycosylation of mucins by use of O-glycodomain reporters recombinantly expressed in glycoengineered HEK293 cells

Mucins and glycoproteins with mucin-like regions contain densely O-glycosylated domains often found in tandem repeat (TR) sequences. These O-glycodomains have traditionally been difficult to characterize because of their resistance to proteolytic digestion, and knowledge of the precise positions of...

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Bibliographic Details
Main Authors: Caval, T. (Author), Clausen, H. (Author), Furukawa, S. (Author), Konstantinidi, A. (Author), Narimatsu, Y. (Author), Nason, R. (Author), Sørensen, D.M (Author), Sun, L. (Author), Vakhrushev, S.Y (Author), Vincentelli, R. (Author), Ye, Z. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Cell-based
Glycoproteins
Glycosylated
Glycosylation
Glycosylations
HEK293 cells
O-Glycans
O-glycosylation
Precise position
Proteolytic digestion
Tandem repeats
Transmembranes
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