Identification of stabilizing point mutations through mutagenesis of destabilized protein libraries
Although there have been recent transformative advances in the area of protein structure prediction, prediction of point mutations that improve protein stability remains challenging. It is possible to construct and screen large mutant libraries for improved activity or ligand binding. However, relia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Biochemistry and Molecular Biology Inc.
2022
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| Subjects: | |
| Online Access: | View Fulltext in Publisher |