Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

Glutathione peroxidase 4 (GPx4) is known for its unique function in the direct detoxification of lipid peroxides in the cell membrane and as a key regulator of ferroptosis, a form of lipid peroxidation–induced nonapoptotic cell death. However, the cytosolic isoform of GPx4 is considered to play a ma...

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Bibliographic Details
Main Authors: Aihara, M. (Author), Azuma, K. (Author), Imai, H. (Author), Iwamoto, R. (Author), Koumura, T. (Author), Matsuoka, M. (Author), Shiraya, T. (Author), Terauchi, R. (Author), Ueta, T. (Author), Watanabe, S. (Author), Yasuda, S. (Author)
Format: Article
Language:English
Published: American Society for Biochemistry and Molecular Biology Inc. 2022
Subjects:
Cell death
Cell survival
Cone photoreceptors
Cytosolic
Detoxification
Glutathione peroxidase
Isoforms
Key regulators
Lipid peroxides
Lipids
Mammals
Mitochondria
Mitochondrial glutathione
Oxidation
Peptides
Rod photoreceptors
Somatic cells
Vision
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