Exploratory study of VVZ-149, a novel analgesic molecule, in the affective component of acute postoperative pain after laparoscopic colorectal surgery

Exploratory study of VVZ-149, a novel analgesic molecule, in the affective component of acute postoperative pain after laparoscopic colorectal surgery

Study objective: VVZ-149 is a small molecule that inhibits the glycine transporter type 2 and the serotonin receptor 5-hydroxytryptamine 2A. In the present study, we investigated the efficacy and safety of VVZ-149 as a single-use injectable analgesic for treating moderate to severe postoperative pai...

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Bibliographic Details
Main Authors: Bai, X. (Author), Bao, X. (Author), Bhandari, A. (Author), Cho, S. (Author), Correll, D.J (Author), Ledley, J.S (Author), Lee, S.R (Author), Nedeljkovic, S.S (Author), Song, I. (Author), Zeballos, J.L (Author), Zhang, Y. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
adult
adverse event
Analgesia, Patient-Controlled
analgesic agent
Analgesics
Analgesics, Opioid
anesthetic recovery
anxiety
Anxiety
area under the curve
Article
catastrophizing
Catastrophizing
clinical effectiveness
clinical outcome
colorectal surgery
Colorectal Surgery
continuous infusion
controlled study
depression
dexamethasone
dizziness
double blind procedure
Double-Blind Method
drug efficacy
drug metabolite
exploratory research
female
fentanyl
general anesthesia
haloperidol
headache
human
Humans
hydromorphone
laparoscopic surgery
laparoscopy
Laparoscopy
lidocaine
loading drug dose
major clinical study
male
maximum plasma concentration
midazolam
middle aged
morphine
multicenter study
narcotic analgesic agent
nausea
numeric rating scale
ondansetron
opiate
pain intensity
Pain, Postoperative
parallel design
patient controlled analgesia
phase 2 clinical trial
placebo
plasma concentration-time curve
postoperative analgesia
postoperative pain
Postoperative pain
preoperative period
procedures
pruritus
randomized controlled trial
somnolence
unclassified drug
United States
university hospital
vvz 149
VVZ-149 injections
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