ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

ADAMTSL2 protein and a soluble biomarker signature identify at-risk non-alcoholic steatohepatitis and fibrosis in adults with NAFLD

Background & Aims: Identifying fibrosis in non-alcoholic fatty liver disease (NAFLD) is essential to predict liver-related outcomes and guide treatment decisions. A protein-based signature of fibrosis could serve as a valuable, non-invasive diagnostic tool. This study sought to identify circulat...

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Bibliographic Details
Main Authors: Corey, K.E (Author), Finkel, N. (Author), Gee, D.W (Author), Gerszten, R.E (Author), Gustafson, J.L (Author), Hutter, M.M (Author), Jacob, J. (Author), Jennings, L.L (Author), Lai, M. (Author), Loureiro, J. (Author), Masia, R. (Author), Meireles, O.R (Author), Ngo, D. (Author), Osganian, S.A (Author), Pitts, R. (Author), Richards, S.M (Author), Ukomadu, C. (Author), Wang, T.J (Author), Witkowski, E.R (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
ADAMTS protein
ADAMTS Proteins
ADAMTSL2
ADAMTSL2 protein, human
adult
Adult
aptamer
Area Under Curve
area under the curve
Article
biological marker
biomarker
Biomarkers
biopsy
Biopsy
blood
case control study
Case-Control Studies
cohort analysis
Cohort Studies
controlled study
disease severity
female
Female
fibrosis
health care quality
human
Humans
liver biopsy
liver cirrhosis
Liver Cirrhosis
liver fibrosis
Logistic Models
major clinical study
male
Male
mass spectrometry
Massachusetts
middle aged
Middle Aged
NAFLD Fibrosis Score
nonalcoholic fatty liver
non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease
nonalcoholic steatohepatitis
non-alcoholic steatohepatitis
pathology
predictive value
procedures
Prospective Studies
prospective study
proteomics
quantitative assay
receiver operating characteristic
ROC Curve
statistical model
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