STK11 Loss: A Novel Mechanism for Melanoma Metastasis with Therapeutic Implications

STK11 is implicated as a tumor suppressor in epithelial cancer invasion and metastasis. In their new article in the Journal of Investigative Dermatology, Dzung et al. (2021) show that loss of STK11 in cutaneous melanoma cells leads to an invasive metastatic phenotype through the activation of the si...

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Bibliographic Details
Main Authors:	Azin, M. (Author), Demehri, S. (Author)
Format:	Article
Language:	English
Published:	Elsevier B.V. 2022
Subjects:	AMPK signaling B Raf kinase biological marker cancer growth cancer immunotherapy cancer inhibition cell adhesion cell invasion cell migration cutaneous melanoma cutaneous melanoma cell line extracellular matrix focal adhesion kinase gene activation human hydroxymethylglutaryl coenzyme A reductase kinase immune checkpoint inhibitor immune evasion loss of function mutation metastatic melanoma microsatellite instability nonhuman Note oncogene N ras pathogenesis phenotype protein depletion protein kinase LKB1 signal transduction skin carcinogenesis STAT3 protein STAT5 protein STAT5a protein STAT5b protein tumor invasion tumor marker tumor microenvironment tumor mutational burden uvomorulin
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View Fulltext in Publisher

STK11 Loss: A Novel Mechanism for Melanoma Metastasis with Therapeutic Implications

Internet

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