Effect of disease progression on the podocyte cell cycle in Alport Syndrome

Effect of disease progression on the podocyte cell cycle in Alport Syndrome

Progression of glomerulosclerosis is associated with loss of podocytes with subsequent glomerular tuft instability. It is thought that a diminished number of podocytes may be able to preserve tuft stability through cell hypertrophy associated with cell cycle reentry. At the same time, reentry into t...

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Bibliographic Details
Main Authors: Clair, G. (Author), Cravedi, P. (Author), De Filippo, R.E (Author), Frank, C.N (Author), Hansen, J.R (Author), Hou, X. (Author), Lemley, K.V (Author), Perin, L. (Author), Petrosyan, A. (Author), Salem, F. (Author), Villani, V. (Author), Zhao, R. (Author)
Format: Article
Language:English
Published: Elsevier B.V. 2022
Subjects:
actin binding protein
Adaptor Proteins, Signal Transducing
Alport syndrome
animal
Animals
cell cycle
Cell Cycle
chronic kidney disease
disease exacerbation
Disease Progression
female
Female
genetics
human
Humans
LIM Domain Proteins
LIM protein
male
Male
metabolism
Mice
Microfilament Proteins
mouse
nephritis
Nephritis, Hereditary
PDLIM2 protein, human
Pdlim2 protein, mouse
podocyte
podocytes
Podocytes
proteomics
Proteomics
signal transducing adaptor protein
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