EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients

EpCAM-positive disseminated cancer cells in bone marrow impact on survival of early-stage NSCLC patients

Introduction: Detection of disseminated cancer cells (DCC) in bone marrow (BM) of patients with early-stage NSCLC has been associated with poor outcome. However, the phenotype, and hence relevant therapy targets, of DCCs in BM are unknown. We therefore compared a classical pan-Cytokeratin (CK) antib...

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Bibliographic Details
Main Authors: Bleicher, S. (Author), Blochberger, I. (Author), Elsner, F. (Author), Großer, C. (Author), Hofmann, H.-S (Author), Klein, C.A (Author), Mederer, T. (Author), Neu, R. (Author), Ried, M. (Author), Robold, T. (Author), Schamberger, T. (Author)
Format: Article
Language:English
Published: Elsevier Ireland Ltd 2022
Subjects:
Article
Biomarker
bone marrow
Bone marrow
bone marrow biopsy
cancer cell
cancer diagnosis
cancer patient
cancer prognosis
cancer specific survival
cancer staging
cancer surgery
cancer survival
clinical feature
clinical outcome
cohort analysis
controlled study
cytokeratin
cytokeratin antibody
disseminated cancer
Disseminated cancer cell
Early dissemination
epithelial cell adhesion molecule
female
gene expression
histopathology
human
human cell
human tissue
Lung cancer
major clinical study
male
metastasis
Metastasis
non small cell lung cancer
outcome assessment
prediction
progression free survival
prospective study
staining
university hospital
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