A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques

Background: Human monoclonal antibody (mAb) treatments are promising for COVID-19 prevention or therapy. The pre-exposure prophylactic efficacy of neutralizing antibodies that are engineered with mutations to extend their persistence in human serum and the neutralizing antibody titer in serum requir...

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Bibliographic Details
Main Authors: Andersen, H. (Author), Barouch, D.H (Author), Carnahan, R.H (Author), Chandrashekar, A. (Author), Chen, R.E (Author), Cobb, R.R (Author), Collins, L. (Author), Cook, A. (Author), Crowe, J.E., Jr (Author), Diamond, M.S (Author), Dorsey, N.M (Author), Earnhart, C.G (Author), Gilchuk, P. (Author), Hackett, K. (Author), Hechenblaickner, M. (Author), Hopkins, S.A (Author), Hoppe, B. (Author), House, R.V (Author), Lewis, M.G (Author), Nkolola, J. (Author), Nonet, G.H (Author), Slaughter, J.C (Author), Snow, D.M (Author), Tomic, M.T (Author), VanBlargan, L.A (Author), Yu, J. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
aerosol
antibody therapeutics
cynomolgus macaques
human monoclonal antibody
neutralizing antibodies
Pre-clinical research
SARS-CoV-2
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