Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription

Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription

Objective: Abdominal adiposity is strongly associated with diabetic and cardiovascular comorbidities. The long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is an important epigenetic regulator with fat depot-specific expression. Its functional roles and epigenetic regulation in abd...

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Bibliographic Details
Main Authors: Chen, P.-Y (Author), Hsu, K.-F (Author), Hsu, Y.-J (Author), Huang, Y.-C (Author), Kuo, F.-C (Author), Lee, C.-H (Author), Lu, C.-H (Author), Wu, L.-W (Author), Yang, H.-Y (Author), Yen, M.-R (Author)
Format: Article
Language:English
Published: Elsevier GmbH 2022
Subjects:
Abdominal adipogenesis
DNA methylation
Epigenetic regulation
HOTAIR
Human body fat distribution
lncRNA
Nervous system development
Subcutaneous adipose tissue
Visceral adipose tissue
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