Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease

Neurogenetic traits outline vulnerability to cortical disruption in Parkinson's disease

The genetic traits that underlie vulnerability to neuronal damage across specific brain circuits in Parkinson's disease (PD) remain to be elucidated. In this study, we characterized the brain topological intersection between propagating connectivity networks in controls and PD participants and...

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Bibliographic Details
Main Authors: Agosta, F. (Author), Basaia, S. (Author), Bueichekú, E. (Author), Caballero-Gaudes, C. (Author), Delgado-Alvarado, M. (Author), Diez, I. (Author), d'Oleire Uquillas, F. (Author), Filippi, M. (Author), Kostic, V.S (Author), Rodriguez-Oroz, M. (Author), Sepulcre, J. (Author), Stojkovic, T. (Author)
Format: Article
Language:English
Published: Elsevier Inc. 2022
Subjects:
adult
alpha synuclein
anatomical variation
Article
autopsy
brain
Brain
brain cortex
brain stem
clinical evaluation
cohort analysis
connectome
Connectomics
controlled study
Cortical Gene Expression
diagnostic imaging
female
fMRI
functional connectivity
functional magnetic resonance imaging
gene expression
gene expression profiling
gene ontology
genetic trait
genetics
hippocampus
histopathology
human
Humans
imaging genetics
immunoreactivity
in vivo study
insula
Lewy body
major clinical study
male
mesencephalon
microtubule
nerve cell network
neuroimaging
neuropathology
occipital gyrus
parietal gyrus
Parkinson disease
Parkinson Disease
Parkinson's disease
pathology
precuneus
protein
snca protein
temporal lobe
thalamus
tongue
transcriptome
unclassified drug
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