Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR-Cas12a system

Highly specific chimeric DNA-RNA-guided genome editing with enhanced CRISPR-Cas12a system

The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas12a system is composed of a Cas12a effector that acts as a DNA-cleaving endonuclease and a crispr RNA (crRNA) that guides the effector to the target DNA. It is considered a key molecule for inducing target-specific gene editin...

Full description

Bibliographic Details
Main Authors: Gwon, L.W (Author), Huh, J.-W (Author), Hur, J.K (Author), Jeong, K.J (Author), Jun, B.-H (Author), Kim, C.H (Author), Kim, H. (Author), Kim, Y.-H (Author), Lee, D.-S (Author), Lee, H. (Author), Lee, K.-R (Author), Lee, S.H (Author), Lee, W.-J (Author), Lee, Y. (Author), Lim, K.-S (Author), Nam, K.-H (Author), Oh, Y. (Author), Song, W. (Author), Won, Y.-S (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
article
chimeric DNA-RNA
clustered regularly interspaced short palindromic repeat
CRISPR Cas system
DNA RNA hybridization
DNA sequence
efficient
en-Cas12a
gene editing
gene therapy
genome editing
highly specific
human
RNA/DNA editing
wild type
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items