Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model

Improving CAR-T cell therapy for solid tumors requires a better understanding of CAR design and cellular composition. Here, we compared second-generation (BBζ and 28ζ) with third-generation (28BBζ) carbonic anhydrase IX (CAIX)-targeted CAR constructs and investigated the antitumor effect of CAR-T ce...

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Main Authors:	Bonal, D.M (Author), Buck, A. (Author), Choueiri, T.K (Author), Culhane, A.C (Author), Freeman, G.J (Author), Grimaud, M. (Author), Huang, Y. (Author), Kodangattil, S. (Author), Marasco, W.A (Author), Nguyen, Q.-D (Author), O'Donnell, M.L (Author), Razimbaud, C. (Author), Signoretti, S. (Author), Wang, Y. (Author), Wei, K. (Author), Zhu, Q. (Author), Zhu, Z. (Author)
Format:	Article
Language:	English
Published:	Cell Press 2022
Subjects:	4-1BB (CD137) CAIX carbonic anhydrase IX CAR-T ccRCC ccRCC orthotopic NSG-SGM3 mouse model chimeric antigen receptor T clear cell renal cell carcinoma scRNA-seq single-cell RNA sequencing
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Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model

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