Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma

Immune checkpoint blockade (CPB) improves melanoma outcomes, but many patients still do not respond. Tumor mutational burden (TMB) and tumor-infiltrating T cells are associated with response, and integrative models improve survival prediction. However, integrating immune/tumor-intrinsic features usi...

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Bibliographic Details
Main Authors: Aguet, F. (Author), Arniella, M.B (Author), Barzily-Rokni, M. (Author), Blackmon, S.M (Author), Blaum, E.M (Author), Boland, G.M (Author), Carrot-Zhang, J. (Author), Chen, J.H (Author), Duncan, L.M (Author), Elagina, L. (Author), Flaherty, K.T (Author), Frederick, D.T (Author), Freeman, S.S (Author), Gabriel, S. (Author), Getz, G. (Author), Gonye, A.L.K (Author), Gushterova, I. (Author), Ha, G. (Author), Hacohen, N. (Author), Hammond, M.R (Author), Jiao, Y.J (Author), Kim, J. (Author), LaSalle, T.J (Author), Lawrence, D.P (Author), Leshchiner, I. (Author), Lin, Z. (Author), Livitz, D. (Author), Meyerson, M. (Author), Ravi, A. (Author), Rosebrock, D. (Author), Sade-Feldman, M. (Author), Sharova, T. (Author), Spiro, O.G (Author), Stemmer-Rachamimov, A.O (Author), Stewart, C. (Author), Sullivan, R.J (Author), Vitzthum von Eckstaedt, H.C (Author), Wargo, J.A (Author), Yizhak, K. (Author)
Format: Article
Language:English
Published: Cell Press 2022
Subjects:
cancer genomics
cancer immunotherapy
immune checkpoint blockade
integrative model
melanoma
melanoma subtype
T cell receptor
TMB
tumor mutational burden
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