Low-coverage whole-genome sequencing of cerebrospinal-fluid-derived cell-free DNA in brain tumor patients

This protocol summarizes the pipeline for analysis of tumor-derived cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) using low-coverage whole-genome sequencing (lcWGS). This approach enables resolution of chromosomal and focal copy-number variations (CNVs) as oncologic signatures, particularly f...

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Bibliographic Details
Main Authors: Kumar, R. (Author), Liu, A.P.Y (Author), Northcott, P.A (Author), Robinson, G.W (Author), Smith, K.S (Author)
Format: Article
Language:English
Published: Cell Press 2022
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Online Access:View Fulltext in Publisher