Low-coverage whole-genome sequencing of cerebrospinal-fluid-derived cell-free DNA in brain tumor patients
This protocol summarizes the pipeline for analysis of tumor-derived cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) using low-coverage whole-genome sequencing (lcWGS). This approach enables resolution of chromosomal and focal copy-number variations (CNVs) as oncologic signatures, particularly f...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
Cell Press
2022
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Subjects: | |
Online Access: | View Fulltext in Publisher |