Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers

A combination of olanzapine and samidorphan (OLZ/SAM) received US Food and Drug Administration approval in May 2021 for the treatment of adults with schizophrenia or bipolar I disorder. OLZ/SAM provides the efficacy of olanzapine, while mitigating olanzapine-associated weight gain. This exploratory...

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Bibliographic Details
Main Authors:	Bajorunas, D. (Author), Beysen, C. (Author), Graham, C. (Author), Jiang, Y. (Author), Martin, W.F (Author), McDonnell, D. (Author), Morrow, L. (Author), Namchuk, M.N (Author), Newcomer, J.W (Author), Silverman, B.L (Author), Toledo, F.G.S (Author)
Format:	Article
Language:	English
Published:	Springer Nature 2022
Subjects:	3-carboxamido-4-hydroxynaltrexone adult Adult alanine aminotransferase Antipsychotic Agents Article aspartate aminotransferase C peptide cholesterol cholesterol blood level clinical trial constipation controlled study disease severity dizziness double blind procedure exploratory research fasting fatigue female glucose Glucose glucose metabolism headache Healthy Volunteers human human experiment Humans hyperinsulinemia hyperinsulinemic-euglycemic clamp technique insulin Insulin insulin metabolism insulin sensitivity male naltrexone Naltrexone narcotic antagonist Narcotic Antagonists neuroleptic agent normal human olanzapine Olanzapine olanzapine plus samidorphan oral glucose tolerance test phase 1 clinical trial placebo randomized controlled trial side effect somnolence United States xerostomia
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Insulin and glucose metabolism with olanzapine and a combination of olanzapine and samidorphan: exploratory phase 1 results in healthy volunteers

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