A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences

Exposure to early-life adversity (ELA) is associated with several neuropsychiatric conditions, including major depressive disorder, yet causality is difficult to establish in humans. Recent work in rodents has implicated impaired reward circuit signaling in anhedonic-like behavior after ELA exposure...

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Bibliographic Details
Main Authors: Baram, T.Z (Author), Kangas, B.D (Author), Luc, O.T (Author), Pizzagalli, D.A (Author), Short, A.K (Author), Stern, H.S (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Subjects:
rat
Online Access:View Fulltext in Publisher