HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis

Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining HSCs activation. However, the mechanisms underl...

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Bibliographic Details
Main Authors: Huang, Y. (Author), Liu, J. (Author), Mao, F. (Author), Mei, R. (Author), Qian, H. (Author), Tan, Y. (Author), Xu, W. (Author), Yan, Y. (Author), Yang, D. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
Subjects:
animal
Animals
beclin 1
Beclin-1
Becn1 protein, mouse
exosome
Exosomes
ferroptosis
Ferroptosis
genetics
hepatic stellate cell
Hepatic Stellate Cells
liver cirrhosis
Liver Cirrhosis
metabolism
Mice
mouse
phospholipid hydroperoxide glutathione peroxidase
Phospholipid Hydroperoxide Glutathione Peroxidase
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