Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse

Micronuclei are DNA-containing structures separate from the nucleus found in cancer cells. Micronuclei are recognized by the immune sensor axis cGAS/STING, driving cancer metastasis. The mitochondrial apoptosis apparatus can be experimentally triggered to a non-apoptotic level, and this can drive th...

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Bibliographic Details
Main Authors: Amer, T. (Author), Badr, M.T (Author), Bavafaye Haghighi, E. (Author), Boerries, M. (Author), Bronsert, P. (Author), Brummer, T. (Author), Fanfone, D. (Author), Glavynskyi, I. (Author), Häcker, G. (Author), Haimovici, A. (Author), Höfer, C. (Author), Ichim, G. (Author), Janssen, K.-P (Author), Öllinger, R. (Author), Rad, R. (Author), Spohr, C. (Author), Thilmany, N. (Author), Weber, A. (Author)
Format: Article
Language:English
Published: Springer Nature 2022
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