Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia

Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8+ T-cell large granular lymphocytic leukemia

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T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common. Although T-LGLL has been described as a chronic T cell response to an antigen, the function of the non-leukemic immune...

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Main Authors: Bhattacharya, D. (Author), Braun, T. (Author), Gurnari, C. (Author), Herling, M. (Author), Huuhtanen, J. (Author), Ishida, F. (Author), Kankainen, M. (Author), Kasanen, T. (Author), Kawakami, T. (Author), Kelkka, T. (Author), Kerr, C. (Author), Lähdesmäki, H. (Author), Lönnberg, T. (Author), Loughran, T. (Author), Maciejewski, J.P (Author), Mustjoki, S. (Author), Rajala, H. (Author), Salmi, M. (Author), Teramo, A. (Author), Theodoropoulos, J. (Author), Zambello, R. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
genetics
human
Humans
large granular lymphocyte leukemia
Leukemia, Large Granular Lymphocytic
lymphocyte antigen receptor
mutation
Mutation
Receptors, Antigen, T-Cell
T lymphocyte
T-Lymphocytes
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