A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

A machine learning algorithm with subclonal sensitivity reveals widespread pan-cancer human leukocyte antigen loss of heterozygosity

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Human leukocyte antigen loss of heterozygosity (HLA LOH) allows cancer cells to escape immune recognition by deleting HLA alleles, causing the suppressed presentation of tumor neoantigens. Despite its importance in immunotherapy response, few methods exist to detect HLA LOH, and their accuracy is no...

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Bibliographic Details
Main Authors: Abbott, C.W (Author), Bartha, G. (Author), Bhave, D.P (Author), Boyle, S.M (Author), Chen, R.O (Author), Dea, S. (Author), Levy, E. (Author), McDaniel, L. (Author), Mellacheruvu, D. (Author), Pyke, R.M (Author), Snyder, M.P (Author), West, J. (Author), Zhang, S.V (Author)
Format: Article
Language:English
Published: Nature Research 2022
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