Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy

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Recent advances in cancer therapeutics clearly demonstrate the need for innovative multiplex therapies that attack the tumour on multiple fronts. Oncolytic or “cancer-killing” viruses (OVs) represent up-and-coming multi-mechanistic immunotherapeutic drugs for the treatment of cancer. In this study,...

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Main Authors: Alkayyal, A. (Author), Alluqmani, N. (Author), Auer, R.C (Author), Austin, B. (Author), Azad, T. (Author), Bell, J.C (Author), Boileau, M. (Author), Boutros, P.C (Author), Brown, E.E.F (Author), Chatterjee, A. (Author), Cottee, M.L (Author), Crawford, N. (Author), Crupi, M.J.F (Author), de Souza, C.T (Author), Diallo, J.-S (Author), Geoffrion, M. (Author), Gibbings, D. (Author), He, X. (Author), Ilkow, C.S (Author), Jacobus, E.J (Author), Jamieson, T. (Author), Jennings, V.A (Author), Keller, B.A (Author), Khan, S.T (Author), Laight, B.J (Author), Mansfield, D. (Author), McKay, H.E (Author), McSweeney, B. (Author), Melcher, A. (Author), Migneco, G. (Author), Pelin, A. (Author), Petryk, J. (Author), Pikor, L. (Author), Poutou, J. (Author), Pugliese, G. (Author), Rayner, K.J (Author), Rezaei, R. (Author), Rose, E. (Author), Roy, D.G (Author), Singaravelu, R. (Author), Surendran, A. (Author), Taha, Z. (Author), tenOever, B.R (Author), Wedge, M.-E (Author), Yamaguchi, T.N (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cancer
cell component
enzyme
enzyme activity
inhibition
inhibitor
molecular analysis
protein
RNA
tumor
virus
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