Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers

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The pancreas is a central organ for human diseases. Most alleles uncovered by genome-wide association studies of pancreatic dysfunction traits overlap with non-coding sequences of DNA. Many contain epigenetic marks of cis-regulatory elements active in pancreatic cells, suggesting that alterations in...

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Bibliographic Details
Main Authors: Acemel, R.D (Author), Bessa, J. (Author), Bordeira-Carriço, R. (Author), Carneiro, F. (Author), Duque, M. (Author), Eufrásio, A. (Author), Ferreira, F.J (Author), Firbas, P.N (Author), Freitas, T. (Author), Galhardo, M. (Author), Goméz-Skarmeta, J.L (Author), Marques, J. (Author), Ribeiro, D. (Author), Teixeira, J. (Author), Tena, J.J (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
animal
Animals
chromatin
Chromatin
Enhancer Elements, Genetic
enhancer region
genetics
genome-wide association study
Genome-Wide Association Study
pancreas
Pancreas
zebra fish
Zebrafish
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