Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip

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Mechanical breathing motions have a fundamental function in lung development and disease, but little is known about how they contribute to host innate immunity. Here we use a human lung alveolus chip that experiences cyclic breathing-like deformations to investigate whether physical forces influence...

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Bibliographic Details
Main Authors: Bai, H. (Author), Belgur, C. (Author), Gilpin, S.E (Author), Goyal, G. (Author), Ingber, D.E (Author), Jiang, A. (Author), Nurani, A. (Author), Oh, C.Y (Author), Patil, A. (Author), Plebani, R. (Author), Powers, R.K (Author), Prantil-Baun, R. (Author), Rodas, M. (Author), Si, L. (Author), Zhai, Y. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
cytokine
Cytokines
Endothelial Cells
endothelium cell
human
Humans
Immunity, Innate
influenza
Influenza A virus (H3N2)
Influenza A Virus, H3N2 Subtype
Influenza, Human
innate immunity
lung
Lung
TRPV Cation Channels
vanilloid receptor
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