Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors

Reprogrammed tracrRNAs enable repurposing of RNAs as crRNAs and sequence-specific RNA biosensors

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In type II CRISPR systems, the guide RNA (gRNA) comprises a CRISPR RNA (crRNA) and a hybridized trans-acting CRISPR RNA (tracrRNA), both being essential in guided DNA targeting functions. Although tracrRNAs are diverse in sequence and structure across type II CRISPR systems, the programmability of c...

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Bibliographic Details
Main Authors: Cooper, J.M (Author), French, C.E (Author), Li, M. (Author), Liu, Y. (Author), Peng, S. (Author), Pinto, F. (Author), Wan, X. (Author), Wang, B. (Author), Xie, Z. (Author), Yang, Z. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
Biosensing Techniques
COVID-19
CRISPR Cas system
CRISPR-Cas Systems
genetic procedures
genetics
guide RNA
human
Humans
metabolism
RNA, Guide
RNA, Viral
SARS-CoV-2
virus RNA
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