Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Non-coding RNA LEVER sequestration of PRC2 can mediate long range gene regulation

Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator required for gene silencing during development. Although PRC2 is a well-established RNA-binding complex, the biological function of PRC2-RNA interaction has been controversial. Here, we study the gene-regulatory role of the inhibitory P...

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Bibliographic Details
Main Authors: Cao, X. (Author), Chai, L. (Author), Gao, C. (Author), Kumar, S.S (Author), Murphy, G.J (Author), Tan, H.K (Author), Tenen, D.G (Author), Teo, W.W (Author), Vanuytsel, K. (Author), Wu, C.-S (Author), Yang, H. (Author), Zhou, Q. (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
chromatin
Chromatin
epsilon-Globins
genetics
hemoglobin epsilon chain
long untranslated RNA
metabolism
polycomb repressive complex 2
Polycomb Repressive Complex 2
protein binding
Protein Binding
RNA, Long Noncoding
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