Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

Human serine racemase (hSR) catalyses racemisation of L-serine to D-serine, the latter of which is a co-agonist of the NMDA subtype of glutamate receptors that are important in synaptic plasticity, learning and memory. In a ‘closed’ hSR structure containing the allosteric activator ATP, the inhibito...

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Bibliographic Details
Main Authors: Atack, J.R (Author), Bax, B.D (Author), Elvers, K.T (Author), Gardiner, S.E (Author), Gillespie, J.A (Author), Grubisha, O. (Author), Harris, T.K (Author), Koulouris, C.R (Author), Mark Roe, S. (Author), Nicholls, R.A (Author), Ward, S.E (Author)
Format: Article
Language:English
Published: Nature Research 2022
Subjects:
adenosine triphosphate
Adenosine Triphosphate
animal
Animals
catalysis
Catalysis
chemistry
genetics
isomerase
Racemases and Epimerases
serine
Serine
serine racemase
tyrosine
Tyrosine
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