An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer

Background and Aims: Genomic alterations that encourage stem cell activity and hinder proper maturation are central to the development of colorectal cancer (CRC). Key molecular mediators that promote these malignant properties require further elucidation to galvanize translational advances. We there...

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Bibliographic Details
Main Authors:	Bala, P. (Author), Bass, A.J (Author), Cejas, P. (Author), Duronio, G.N (Author), Hebbar, P. (Author), Liang, X. (Author), Long, H.W (Author), Sahgal, P. (Author), Sethi, N.S (Author), Singh, H. (Author), Spisak, S. (Author), Xie, Y. (Author), Yang, Y. (Author), Zhang, Y. (Author)
Format:	Article
Language:	English
Published:	W.B. Saunders 2022
Subjects:	AC133 Antigen adenoma adult animal animal experiment animal model animal tissue Animals Article cancer growth cancer stem cell CD133 antigen cell activity cell differentiation Cell Differentiation cell proliferation Cell Proliferation chromatin immunoprecipitation sequencing clinical outcome colorectal cancer Colorectal Cancer colorectal cancer cell line colorectal carcinoma Colorectal Neoplasms colorectal tumor controlled study Differentiation Block ectopic expression Enhancer Elements, Genetic enhancer region epigenetics feedback system gene expression profiling gene expression regulation Gene Expression Regulation, Neoplastic gene overexpression Genes, APC genetics genome-wide association study HCC cell line (colorectal cancer) histone histone modification histopathology HT-29 cell line HT29 Cells human human cell human tissue Humans immunohistochemistry in vitro study intestinal organoid intestinal stem cell intestine tissue intestine tumor intron membrane protein metabolism Mice, Transgenic molecular biology mouse Neoplastic Stem Cells nonhuman Paneth cell pathology positive feedback PROM1 PROM1 protein, human Prom1 protein, mouse prominin 1 protein binding protein domain protein expression level protein function regulatory mechanism RNA sequencing signal transduction SOX9 SOX9 protein, human Sox9 protein, mouse SOX9 Transcription Factor tissue differentiation transcription factor transcription factor Sox9 transcription regulation transgenic mouse Tumor Burden tumor cell culture Tumor Cells, Cultured tumor growth tumor suppressor gene tumor volume unclassified drug upregulation Wnt protein Wnt signaling Wnt Signaling Pathway
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An Enhancer-Driven Stem Cell–Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer

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