Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis

Epithelial X-Box Binding Protein 1 Coordinates Tumor Protein p53-Driven DNA Damage Responses and Suppression of Intestinal Carcinogenesis

Background & Aims: Throughout life, the intestinal epithelium undergoes constant self-renewal from intestinal stem cells. Together with genotoxic stressors and failing DNA repair, this self-renewal causes susceptibility toward malignant transformation. X-box binding protein 1 (XBP1) is a stress...

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Main Authors: Aden, K. (Author), Arnold, P. (Author), Blumberg, R. (Author), Das, S. (Author), Hang, X. (Author), Ito, G. (Author), Jesinghaus, M. (Author), Kaikkonen, L. (Author), Kakavand, N. (Author), Kaser, A. (Author), Laue, G. (Author), Mishra, N. (Author), Ogris, C. (Author), Plattner, C. (Author), Roecken, C. (Author), Rosenstiel, P. (Author), Saur, D. (Author), Schreiber, S. (Author), Silva, M.G (Author), Stengel, S. (Author), Tengen, F. (Author), Trajanoski, Z. (Author), Tran, F. (Author), Tschurtschenthaler, M. (Author), Welz, L. (Author), Wottawa, F. (Author)
Format: Article
Language:English
Published: W.B. Saunders 2022
Subjects:
Adaptor Proteins, Signal Transducing
adenocarcinoma
Adenocarcinoma
adenoma
Adenoma
animal
Animals
cell cycle protein
Cell Cycle Proteins
cell transformation
Cell Transformation, Neoplastic
CRC
Databases, Genetic
Ddit4l protein, mouse
DNA damage
DNA Damage
drug effect
Eif4ebp1 protein, mouse
endoplasmic reticulum stress
Endoplasmic Reticulum Stress
Epithelial Cells
epithelium cell
gene expression regulation
Gene Expression Regulation, Neoplastic
gene regulatory network
Gene Regulatory Networks
genetic database
genetics
human
Humans
Intestinal Epithelial Cell
Intestinal Mucosa
Intestinal Neoplasms
intestine mucosa
intestine tumor
knockout mouse
mammalian target of rapamycin inhibitor
metabolism
Mice, Knockout
MTOR Inhibitors
p53
pathology
protein p53
signal transducing adaptor protein
signal transduction
Signal Transduction
sirolimus
Sirolimus
TP53 protein, human
Trp53 protein, mouse
Tumor Suppressor Protein p53
X box binding protein 1
X-Box Binding Protein 1
XBP1
XBP1 protein, human
Xbp1 protein, mouse
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