MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer

MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer

The oncogenic MUC1-C protein drives dedifferentiation of castrate resistant prostate cancer (CRPC) cells in association with chromatin remodeling. The present work demonstrates that MUC1-C is necessary for expression of IFNGR1 and activation of the type II interferon-gamma (IFN-γ) pathway. We show t...

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Bibliographic Details
Main Authors: Bhattacharya, A. (Author), Fushimi, A. (Author), Hagiwara, M. (Author), Hu, Q. (Author), Kufe, D. (Author), Liu, S. (Author), Liu, T. (Author), Long, M.D (Author), Morimoto, Y. (Author), Oya, M. (Author), Withers, H.G (Author), Wong, K.K (Author), Yamashita, N. (Author)
Format: Article
Language:English
Published: Taylor and Francis Ltd. 2022
Subjects:
Article
barrier to autointegration factor
cancer stem cell
castration resistant prostate cancer
chromatin assembly and disassembly
chromatin immunoprecipitation
cohort analysis
coimmunoprecipitation
CRPC
FBXW7 ubiquitin E3 ligase
gamma interferon
gamma interferon receptor 1
gene silencing
human
human cell
IDO1 protein
IFN-gamma
immune evasion
immunoblotting
immunosuppression
immunosuppressive treatment
inflammation
interferon regulatory factor 1
ISG15 protein
male
metabolite
MUC1-C
mucin 1
PBRM1
PTGES protein
real time reverse transcription polymerase chain reaction
serine proteinase inhibitor
single cell RNA seq
STAT1 protein
T lymphocyte
tumor microenvironment
type II interferon signaling
ubiquitin protein ligase E3
unclassified drug
WARS protein
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