Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function

Obesity is one of the leading preventable causes of cancer; however, little is known about the effects of obesity on anti-tumor immunity. Here, we investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. Our findings revealed that CD8 T cell infiltrati...

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Bibliographic Details
Main Authors: Brennan, D. (Author), Chouchani, E.T (Author), Doughty, M. (Author), Douglas, A. (Author), Dyck, L. (Author), Fabre, A. (Author), Heneghan, H. (Author), Hogan, A. (Author), Leroux, C. (Author), Loftus, R.M (Author), Lynch, L. (Author), McCormack, J. (Author), Mills, E.L (Author), Moran, B. (Author), O’shea, D. (Author), Prendeville, H. (Author), Raverdeau, M. (Author), Wilk, M.M (Author), Wilkinson, M. (Author)
Format: Article
Language:English
Published: Rockefeller University Press 2022
Subjects:
amino acid
Amino Acids
animal
Animals
CD8+ T lymphocyte
CD8-Positive T-Lymphocytes
Diet, High-Fat
disease model
Disease Models, Animal
immunology
immunotherapy
Immunotherapy
Innate immunity and inflammation
lipid diet
lymphocyte count
Lymphocyte Count
Lymphocytes, Tumor-Infiltrating
metabolism
Metabolism
Mice
Mice, Obese
mouse
mouse mutant
neoplasm
Neoplasms
obesity
Obesity
pathology
tumor associated leukocyte
Tumor immunology
tumor microenvironment
Tumor Microenvironment
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