NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens

NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens

OBJECTIVES: Salivary gland acinic cell carcinoma (AciCC) has recognizable cytomorphologic features that can overlap with benign and malignant entities, creating a diagnostic challenge. AciCC harbors a t(4;9) translocation increasing nuclear receptor subfamily 4 group A member 3 (NR4A3) expression, d...

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Bibliographic Details
Main Authors: Asiry, S. (Author), Beg, S. (Author), Cantley, R. (Author), Faquin, W.C (Author), He, B. (Author), Katabi, N. (Author), Lubin, D.J (Author), Maleki, Z. (Author), Nakaguro, M. (Author), Rao, R. (Author), Sadow, P.M (Author), Scognamiglio, T. (Author), Shi, Q. (Author), Siddiqui, M.T (Author), Viswanathan, K. (Author), Zhang, T. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
acinar cell carcinoma
Acinic cell carcinoma
Biomarkers, Tumor
Carcinoma, Acinar Cell
Carcinoma, Mucoepidermoid
DNA binding protein
DNA-Binding Proteins
genetics
human
Humans
immunohistochemistry
Immunohistochemistry
mucoepidermoid tumor
NR4A3
NR4A3 protein, human
Oncocytic
Receptors, Steroid
Receptors, Thyroid Hormone
Salivary
Salivary Gland Neoplasms
salivary gland tumor
steroid receptor
thyroid hormone receptor
tumor marker
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