Multiplexed Assay to Quantify the PP-Fold Family of Peptides in Human Plasma Using Microflow Liquid Chromatography-Tandem Mass Spectrometry

Multiplexed Assay to Quantify the PP-Fold Family of Peptides in Human Plasma Using Microflow Liquid Chromatography-Tandem Mass Spectrometry

Background: Peptide Tyr-Tyr (PYY1-36), pancreatic polypeptide (PP1-36) and neuropeptide Y (NPY1-36) constitute the PP-fold family of peptides that is involved in metabolic regulation. Very low plasma concentrations and cleavage into active 3-36 fragments challenge bioanalytical assays used for the q...

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Bibliographic Details
Main Authors: Bally, L. (Author), Eugster, P.J (Author), Grouzmann, E. (Author), Herzig, D. (Author), Kuenzli, C. (Author), Nakas, C.T (Author), Reverter-Branchat, G. (Author), Rindlisbacher, B. (Author), Stauffer, T. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
DPP4
immunoassay
micro-UHPLC-MS/MS
neuropeptide Y (NPY)
pancreatic polypeptide (PP)
peptide YY (PYY)
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