RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes

RNA sequencing-based screen for reactivation of silenced alleles of autosomal genes

In mammalian cells, maternal and paternal alleles usually have similar transcriptional activity. Epigenetic mechanisms such as X-chromosome inactivation (XCI) and imprinting were historically viewed as rare exceptions to this rule. Discovery of autosomal monoallelic autosomal expression (MAE) a deca...

Full description

Bibliographic Details
Main Authors: Alves-Pereira, C.F (Author), Bortvin, A. (Author), Gimelbrant, A.A (Author), Gupta, S. (Author), Igarashi, K.J (Author), Lafontaine, D.L (Author), Mendelevich, A. (Author), Nag, A. (Author), Vigneau, S. (Author), Vinogradova, S. (Author)
Format: Article
Language:English
Published: Genetics Society of America 2022
Subjects:
allele
Alleles
Allelic expression
allelic imbalance
animal
Animals
article
chromosome
Chromosomes
controlled study
DNA demethylation
DNA methylation
DNA Methylation
gene control
gene expression
Gene regulation
gene silencing
genetics
genome imprinting
Genomic Imprinting
mitosis
prevalence
protein expression
RNA sequencing
sequence analysis
Sequence Analysis, RNA
X chromosome inactivation
X Chromosome Inactivation
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items