The effect of weak clonal interference on average fitness trajectories in the presence of macroscopic epistasis

Adaptation dynamics on fitness landscapes is often studied theoretically in the strong-selection, weak-mutation regime. However, in a large population, multiple beneficial mutants can emerge before any of them fixes in the population. Competition between mutants is known as clonal interference, and...

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Bibliographic Details
Main Authors: Amir, A. (Author), Guo, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
Online Access:View Fulltext in Publisher