Parental Life Span and Polygenic Risk Score of Longevity Are Associated With White Matter Hyperintensities

Parental Life Span and Polygenic Risk Score of Longevity Are Associated With White Matter Hyperintensities

Human longevity is moderately heritable and is hence influenced by both genetic and environmental factors. However, there remains considerable uncertainty regarding its relationship with brain aging. Here, we used a discovery sample (N = 19 136, aged 45-81 years) from the UK Biobank and a replicatio...

Full description

Bibliographic Details
Main Authors: Brodaty, H. (Author), Dong, C. (Author), Jiang, J. (Author), Mather, K.A (Author), Sachdev, P.S (Author), Thalamuthu, A. (Author), Wen, W. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
aged
Aged
Aged, 80 and over
Australia
Brain volumetric metrics
child parent relation
diagnostic imaging
genetics
human
Humans
longevity
Longevity
Magnetic Resonance Imaging
male
Male
nuclear magnetic resonance imaging
Parents
pathology
Polygenic risk score
procedures
risk factor
Risk Factors
very elderly
white matter
White Matter
White matter hyperintensities
Online Access:View Fulltext in Publisher

Internet

View Fulltext in Publisher

Similar Items