Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues

Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues

Carotid intima media thickness (cIMT) is a biomarker of subclinical atherosclerosis and a predictor of future cardiovascular events. Identifying associations between gene expression levels and cIMT may provide insight to atherosclerosis etiology. Here, we use two approaches to identify associations...

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Main Authors: Below, J.E (Author), Beutner, F. (Author), Bis, J.C (Author), Castaneda, A.B (Author), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Subclinical Working Group (Author), de Vries, P.S (Author), Dehghan, A. (Author), Dhana, K. (Author), Dörr, M. (Author), Franceshini, N. (Author), Franco, O.H (Author), Giambartolomei, C. (Author), Herder, C. (Author), Hofman, A. (Author), Homuth, G. (Author), Hwang, S.-J (Author), Jansen, R. (Author), Kavousi, M. (Author), Kirsten, H. (Author), Koenig, W. (Author), Krohn, K. (Author), Levy, D. (Author), Loeffler, M. (Author), Marzi, C. (Author), Meisinger, C. (Author), O'Donnell, C.J (Author), Penninx, B.W.J.H (Author), Peters, A. (Author), Peters, M.J (Author), Petty, L.E (Author), Polak, J. (Author), Prokisch, H. (Author), Rathmann, W. (Author), Schminke, U. (Author), Scholz, M. (Author), Schramm, K. (Author), Seissler, J. (Author), Seldenrijk, A. (Author), Thiery, J. (Author), Uitterlinden, A.G (Author), van Grootheest, G. (Author), van Meurs, J.B.J (Author), Völzke, H. (Author), Waldenberger, M. (Author), Weiss, S. (Author), Wolf, P. (Author), Zhang, X. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
arterial wall thickness
atherosclerosis
Atherosclerosis
Carotid Intima-Media Thickness
gene expression
Gene Expression
genome-wide association study
Genome-Wide Association Study
human
Humans
risk factor
Risk Factors
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