The mutation c.346-1G > A in SOHLH1 impairs sperm production in the homozygous but not in the heterozygous condition

The mutation c.346-1G > A in SOHLH1 impairs sperm production in the homozygous but not in the heterozygous condition

Non-obstructive azoospermia (NOA) is an important cause of male infertility, and the genetic pathogenesis is still incompletely understood. The previous study reported that heterozygous mutation of c.346-1G > A in spermatogenesis and oogenesis specific basic helix-loop-helix 1 (SOHLH1) was identi...

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Bibliographic Details
Main Authors: Chen, S. (Author), Liu, M. (Author), Shen, Y. (Author), Wang, Y. (Author), Yang, Y. (Author)
Format: Article
Language:English
Published: NLM (Medline) 2022
Subjects:
animal
Animals
azoospermia
Azoospermia
basic helix loop helix transcription factor
Basic Helix-Loop-Helix Transcription Factors
genetics
homozygote
Homozygote
human
Humans
male
Male
Mice
mouse
mutation
Mutation
Sohlh1 protein, mouse
spermatogenesis
Spermatogenesis
Spermatozoa
spermatozoon
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