The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase

Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin occupancy, and stability, however the molecular basis rema...

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Bibliographic Details
Main Authors: Ahlner, A. (Author), Andrews, D.W (Author), Arrowsmith, C.H (Author), Duan, S. (Author), Houliston, S. (Author), Johansson-Åkhe, I. (Author), Kenney, T.M.G (Author), Lemak, A. (Author), Morad, V. (Author), Penn, L.Z (Author), Redel, C. (Author), Sunnerhagen, M. (Author), Tamachi, A. (Author), Wallner, B. (Author), Wei, Y. (Author)
Format: Article
Language:English
Published: Oxford University Press 2022
Subjects:
chromatin
Chromatin
DNA binding protein
DNA-Binding Proteins
genetics
human
Humans
metabolism
nuclear protein
Nuclear Proteins
Oncogene Proteins
oncoprotein
phosphoprotein phosphatase 1
Protein Phosphatase 1
RNA binding protein
RNA-Binding Proteins
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