The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase
Despite MYC dysregulation in most human cancers, strategies to target this potent oncogenic driver remain an urgent unmet need. Recent evidence shows the PP1 phosphatase and its regulatory subunit PNUTS control MYC phosphorylation, chromatin occupancy, and stability, however the molecular basis rema...
Main Authors: | Ahlner, A. (Author), Andrews, D.W (Author), Arrowsmith, C.H (Author), Duan, S. (Author), Houliston, S. (Author), Johansson-Åkhe, I. (Author), Kenney, T.M.G (Author), Lemak, A. (Author), Morad, V. (Author), Penn, L.Z (Author), Redel, C. (Author), Sunnerhagen, M. (Author), Tamachi, A. (Author), Wallner, B. (Author), Wei, Y. (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
Oxford University Press
2022
|
Subjects: | |
Online Access: | View Fulltext in Publisher |
Similar Items
-
Analysis of predictive power of binding affinity of PBM-derived sequences
by: Matereke, Lavious Tapiwa
Published: (2015) -
Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.
Published: (2013) -
Analyzing the Surface Structure of the Binding Domain on DNA and RNA Binding Proteins
by: Wei Wang, et al.
Published: (2019-01-01) -
Divergence of the mRNA targets for the Ssb proteins of bacteriophages T4 and RB69
by: Petrov Vasiliy M, et al.
Published: (2004-09-01) -
Compartmentalization and Functionality of Nuclear Disorder: Intrinsic Disorder and Protein-Protein Interactions in Intra-Nuclear Compartments
by: Fanchi Meng, et al.
Published: (2015-12-01)